刘清飞-清华大学北京市中医药交叉研究所

个人简介

现任医学院-药学院党委副书记，药学院实验教学中心主任。1993年毕业于陕西中医学院药学系，获学士学位；2000年毕业于南京中医药大学中药学院，获硕士学位；2003年毕业于广州中医药大学中药学院，获博士学位；2003-2005年于清华大学化学系从事博士后研究工作；2005年于清华大学医学院工作，其中2009年于比利时鲁汶大学生物系从事博士后研究工作；2016年起于清华大学药学院（原医学院药学系）工作。主持或参与欧盟Horizon2020、国家自然科学基金、科技部科技攻关、973计划、863计划、粤港澳科技合作、中国博士后科研课题（一等）等科研项目20余项。出版合著专著3部，参与翻译著作1部（《白宫补充与替代医学工作委员会报告》）。其中《中医药系统生物学》为国内外第一部中医药系统生物学研究专著。发表SCI收录论文30余篇。申请中国发明专利10余项、国际专利1项，已授权6项。

课程教学

《药剂学》，《药剂学实验》，《药学综合实验》，《药学社会实践》，《中医药科学研究进展》。

研究方向

（1）药物新剂型与新技术的研究开发。如通过缓控释制剂的开发提高药物的口服或经皮给药的生物利用度；通过药物-载体分子间作用力的分析，优化脂质体等纳米药物制剂配方，提高包封率、载药量及稳定性；通过打印材料的优化设计，进行3D打印药物剂型设计与制剂制备；采用NIR，对药物生产过程进行快速分析、无损检测。

（2）中药物质基础与作用机理研究。基于成分分析、组学研究及药效评价，对中药材及中药复方进行物质基础与作用机理研究，以期进一步开发中药新药。抗真菌、抗生殖衰老研究获得清华-鲁汶基金、欧盟Horizon2020、科技部重点项目支持。

（3）药物代谢动力学研究。对小分子药物、中药活性成分、药物新剂型进行药物代谢动力学研究；基于LC/MS检测、计算方法开发、化学合成，发现药物的体内代谢产物。

发表文章

专著

1. Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu. System biology for TCM, John Wiley Press, 2012；

2. 罗国安，王义明，梁琼麟， 刘清飞。中医药系统生物学。科学出版社，2011年；

3. 药物新剂型。编委，化学工业出版社，2003

文章

1. Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S.Rattan. A geing with elegans: a research proposal to map healthspan pathways. Biogerontology, 2016, 17(4): 771-782

2. Donglin He, Shuhui Yin, Fuguo Han, Jingjie Zhu, Zhiyuan Tong, Qingfei Liu. Pharmacokinetics and Tissue Distribution of Two Novel Isomerism Anticancer Platinum Compounds. Drug Dev Ind Pharm, 2016, in press

3. Zhengguang Li, Rui Zhang, Xiuping Wang, Xiaofei Hu, Yuguo Chen, Qingfei Liu. Simultaneous determination of seven ginsenosides in rat plasma by high performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection. Biomed Chromatogr, 2015, 29(2): 167-175

4. Jun Shi, Wenjuan Cong, Yiming Wang, Qingfei Liu, Guoan Luo. Synergistic Effect and Mechanism of Cineole and Terpineol on in vitro Transdermal Delivery of Huperzine A from Microemulsions. Iran J Pharm Res. 2013, 12(2):271-80

5. Qingfei Liu, Yun Shi, Tuo Guo, Yong Wang, Wenjuan Cong, Jingjie Zhu. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. J Chromatogr B, 2012, 907, 146-153

6． Qingfei Liu, Walter Luyten, Klaartje Pellens, Yiming Wang, Wei Wang, Karin Thevissen, Qionglin Liang, Bruno P.A. Cammue, Liliane Schoofs, Guoan Luo. Screening for Antifungal Plants from Chinese Traditional and Folk Medicines, J Ethnopharm, 2012, 143(3): 772-778

7. Wenjuan Cong, Jun Shi, Yiming Wang, Qingfei Liu, Guoan Luo. Molecular Mechanism Study on the Cumulative Cardiotoxicity of a Pirarubicin Liposome Powder. Talanta, 2012, 89: 91-98

8. Jun Shi, Wenjuan Cong, Yiming Wang, Qingfei Liu, Guoan Luo. Microemulsion-based Patch for Transdermal Delivery of Huperzine A and Ligustrazine Phosphate. Drug Dev Ind Pharm, 2012, 38(6): 752-761

9．Jun Shi, Qingfei Liu, Yiming Wang, Guoan Luo. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. Pharmacol Biochem Beh, 2010, 96: 449-453

10．Juan Lu, Changmei Cheng, Xinge Zhao, Qingfei Liu, Ping Yang, Yiming Wang, Guoan Luo. PEG-scutellarin Prodrugs: Synthesis and Efficacy Studies. Eur J Med Chem, 2010, 45(5): 1731-1738

11. Wenjuan Cong, Qingfei Liu, Xi Chen, Rong Gao, Juan Lu, Yiming Wang, Guoan Luo. Characterization and Pharmacokinetics of a Novel Pirarubicin Liposome Powder. Drug Dev Ind Pharm, 2010, 143:154-160

12. Juan Lu, Qingfei Liu, Xinge Zhao, Rong Gao, Wenjuan Cong, Yiming Wang, Guoan Luo. Simultaneous RP-LC Determination of the Prodrug Scu-PEG and its Metabolite Scutellarin in Rat Plasma. Chromatographia, 2010, 71(5-6), 511-515

13. Qingfei Liu, Yun Shi, Yong Wang, Juan Lu, Wenjuan Cong, Guoan Luo, Yiming Wang. Metabolism profile of scutellarin in rat urine following oral administration by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Talanta, 2009, 80: 84-91

14. Qingfei Liu，Yun Shi, Yuzhen Zhang, Zhongmin Song, Qiang Su, Yu Zhang, Guoan Luo. A Simple and Rapid Method for Determination of Pennogenin Diglycoside in Rat Plasma by High Performance Liquid Chromatography Mass Spectrometry: Application to the Pharmacokinetics of Gongxuening Capsules. J Chromatogr Sci, 2009, 47 (8): 728-732

15. Qingfei Liu, Xue Li, Qiang Su，Guoan Luo, Yiming Wang, Weiping Liu. Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats. Arch Pharm Resh, 2009, 32 (11): 1621-1628

16. Wenjuan Cong, Qingfei Liu, Yiming Wang, Guoan Luo. Investigation on the interactions between pirarubicin and phospholipids. Biophs Chem, 2009, 143: 154-160

17. Su Qiang, Liu Qingfei, Wang Yong, Bi Kaishun, Luo Guoan. Rapid and sensitive assay on the main components in Shuang-Huang-Lian preparations by UPLC-TOF-MS. Chem Res Chin Univ, 2009, 25(1): 122-124

18. Xueyan Duan, Qingfei Liu, Yu Zhang, Kaishun Bi, Xi Chen, Yiming Wang, Guoan Luo. Development of Monolithic Osmotic Pump Tablet System for isosorbide-5mononitrate Delivery and Evaluation of It In Vitro and In Vivo. Drug Dev Ind Pharm, 2009, 35(4): 499-507